Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

Parkinson disease (PD) is the most common neurodegenerative movement disorder. An increase in the amount of α-synuclein protein could constitute a cause of PD. α-Synuclein is degraded at least partly by chaperone-mediated autophagy (CMA). The I93M mutation in ubiquitin C-terminal hydrolase L1 (UCH-L...

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Bibliografiske detaljer
Main Authors: Kabuta, Tomohiro, Furuta, Akiko, Aoki, Shunsuke, Furuta, Koh, Wada, Keiji
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259779/
https://ncbi.nlm.nih.gov/pubmed/18550537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801918200
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