Loss of β-Glucocerebrosidase Activity Does Not Affect Alpha-Synuclein Levels or Lysosomal Function in Neuronal Cells

To date, a plethora of studies have provided evidence favoring an association between Gaucher disease (GD) and Parkinson’s disease (PD). GD, the most common lysosomal storage disorder, results from the diminished activity of the lysosomal enzyme β-glucocerebrosidase (GCase), caused by mutations in t...

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Hlavní autoři: Dermentzaki, Georgia, Dimitriou, Evangelia, Xilouri, Maria, Michelakakis, Helen, Stefanis, Leonidas
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620326/
https://ncbi.nlm.nih.gov/pubmed/23580063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060674
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