Complex Effects of the ZSCAN21 Transcription Factor on Transcriptional Regulation of α-Synuclein in Primary Neuronal Cultures and in Vivo

α-Synuclein, a presynaptic neuronal protein encoded by the SNCA gene, is strongly implicated in Parkinson disease (PD). PD pathogenesis is linked to increased SNCA levels; however, the transcriptional elements that control SNCA expression are still elusive. Previous experiments in PC12 cells demonst...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Dermentzaki, Georgia, Paschalidis, Nikolaos, Politis, Panagiotis K., Stefanis, Leonidas
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Gene Regulation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861444/
https://ncbi.nlm.nih.gov/pubmed/26907683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704973
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!
Laddar...

Liknande verk