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Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation
Lysosomal dysfunction is a common pathological feature of neurodegenerative diseases. GTP-binding protein type A1 (GBA1) encodes β-glucocerebrosidase 1 (GCase 1), a lysosomal hydrolase. Homozygous mutations in GBA1 cause Gaucher disease, the most common lysosomal storage disease, while heterozygous...
Gorde:
| Argitaratua izan da: | Exp Mol Med |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351412/ https://ncbi.nlm.nih.gov/pubmed/25813221 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2014.128 |
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