Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration

Mutations in the glucosidase, beta, acid (GBA1) gene cause Gaucher’s disease, and are the most common genetic risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) excluding variants of low penetrance. Because α-synuclein-containing neuronal aggregates are a defining feature o...

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Bibliografiska uppgifter
I publikationen:PLoS Genet
Huvudupphovsmän: Davis, Marie Y., Trinh, Kien, Thomas, Ruth E., Yu, Selina, Germanos, Alexandre A., Whitley, Brittany N., Sardi, Sergio Pablo, Montine, Thomas J., Pallanck, Leo J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809718/
https://ncbi.nlm.nih.gov/pubmed/27019408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005944
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