Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson’s disease (PD). The spread of brain protein aggregates is associated with clinical disease progression, but how this occurs remains unclear. Mutations in glucosidase, beta acid 1 (GBA), which encodes glucocerebrosid...

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Udgivet i:PLoS Genet
Main Authors: Jewett, Kathryn A., Thomas, Ruth E., Phan, Chi Q., Lin, Bernice, Milstein, Gillian, Yu, Selina, Bettcher, Lisa F., Neto, Fausto Carnevale, Djukovic, Danijel, Raftery, Daniel, Pallanck, Leo J., Davis, Marie Y.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888665/
https://ncbi.nlm.nih.gov/pubmed/33539341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008859
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