Glucocerebrosidase reduces the spread of protein aggregation in a Drosophila melanogaster model of neurodegeneration by regulating proteins trafficked by extracellular vesicles

Abnormal protein aggregation within neurons is a key pathologic feature of Parkinson’s disease (PD). The spread of brain protein aggregates is associated with clinical disease progression, but how this occurs remains unclear. Mutations in glucosidase, beta acid 1 (GBA), which encodes glucocerebrosid...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Jewett, Kathryn A., Thomas, Ruth E., Phan, Chi Q., Lin, Bernice, Milstein, Gillian, Yu, Selina, Bettcher, Lisa F., Neto, Fausto Carnevale, Djukovic, Danijel, Raftery, Daniel, Pallanck, Leo J., Davis, Marie Y.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7888665/
https://ncbi.nlm.nih.gov/pubmed/33539341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008859
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