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Targeted Overexpression of Human Alpha-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

Microglial activation and adaptive immunity have been implicated in the neurodegenerative processes in Parkinson disease. It has been proposed that these responses may be triggered by modified forms of α-synuclein (αSYN), particularly nitrated species, which are released as a consequence of dopamine...

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Detalhes bibliográficos
Main Authors: Theodore, Shaji, Cao, Shuwen, McLean, Pamela J., Standaert, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753200/
https://ncbi.nlm.nih.gov/pubmed/19018246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e31818e5e99
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