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SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Sirtuins are NAD(+)-dependent protein deacetylases that are highly conserved and counter aging in lower organisms. We show that the life sp...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263206/ https://ncbi.nlm.nih.gov/pubmed/22219275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3442-11.2012 |
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