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SIRT1 Suppresses β-amyloid Production by Activating the α-Secretase Gene ADAM10

A hallmark of Alzheimer's disease (AD) is the accumulation of plaques of Aβ 1-40 and 1-42 peptides, which result from the sequential cleavage of APP by the β and γ-secretases. The production of Aβ peptides is avoided by alternate cleavage of APP by the α and γ-secretases. Here we show that prod...

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Bibliografiske detaljer
Main Authors: Donmez, Gizem, Wang, Diana, Cohen, Dena E., Guarente, Leonard
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2911635/
https://ncbi.nlm.nih.gov/pubmed/20655472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.020
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