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SIRT1 Suppresses β-amyloid Production by Activating the α-Secretase Gene ADAM10
A hallmark of Alzheimer's disease (AD) is the accumulation of plaques of Aβ 1-40 and 1-42 peptides, which result from the sequential cleavage of APP by the β and γ-secretases. The production of Aβ peptides is avoided by alternate cleavage of APP by the α and γ-secretases. Here we show that prod...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911635/ https://ncbi.nlm.nih.gov/pubmed/20655472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.020 |
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