ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterized from Escherichia coli, is a competitive inhibitor...

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Detaylı Bibliyografya
Asıl Yazarlar: Moss, Marcia L., Powell, Gary, Miller, Miles A., Edwards, Lori, Qi, Bin, Sang, Qing-Xiang Amy, De Strooper, Bart, Tesseur, Ina, Lichtenthaler, Stefan F., Taverna, Mara, Zhong, Julia Li, Dingwall, Colin, Ferdous, Taheera, Schlomann, Uwe, Zhou, Pei, Griffith, Linda G., Lauffenburger, Douglas A., Petrovich, Robert, Bartsch, Jörg W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Enzymology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220463/
https://ncbi.nlm.nih.gov/pubmed/21956108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280495
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