Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain

Dysregulation of ErbB-family signaling underlies numerous pathologies and has been therapeutically targeted through inhibiting ErbB-receptors themselves or their cognate ligands. For the latter, “decoy” antibodies have been developed to sequester ligands including heparin-binding epidermal growth fa...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Miller, Miles A., Moss, Marcia L., Powell, Gary, Petrovich, Robert, Edwards, Lori, Meyer, Aaron S., Griffith, Linda G., Lauffenburger, Douglas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609913/
https://ncbi.nlm.nih.gov/pubmed/26477568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15150
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