The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release

Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree of proteolytic release of the ligand. Although the spatial range of diffusion o...

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Detalhes bibliográficos
Main Authors: Prince, Robin N., Schreiter, Eric R., Zou, Peng, Wiley, H. Steven, Ting, Alice Y., Lee, Richard T., Lauffenburger, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886746/
https://ncbi.nlm.nih.gov/pubmed/20530570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.058321
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