The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells

AIM: To test the hypothesis that the epoxyeicosatrienoic acid (EET)-induced transactivation of EGF-R depends on the activation of metalloproteinases and the subsequent release of HB-EGF in cancer cells. METHODS: Exogenous 14,15-EET were added to four human-derived cancer cell lines Tca-8113, A549, H...

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Detalhes bibliográficos
Main Authors: Cheng, Li-ming, Jiang, Jian-gang, Sun, Zi-yong, Chen, Chen, Dackor, Ryan T, Zeldin, Darryl C, Wang, Dao-wen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3938287/
https://ncbi.nlm.nih.gov/pubmed/20139904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2009.184
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