Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF

Cleavage of membrane-anchored heparin-binding EGF-like growth factor (proHB-EGF) via metalloprotease activation yields amino- and carboxy-terminal regions (HB-EGF and HB-EGF-C, respectively), with HB-EGF widely recognized as a key element of epidermal growth factor receptor transactivation in G prot...

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Bibliographic Details
Main Authors: Nanba, Daisuke, Mammoto, Akiko, Hashimoto, Koji, Higashiyama, Shigeki
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173632/
https://ncbi.nlm.nih.gov/pubmed/14597771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303017
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