Telmisartan Inhibits Cell Proliferation by Blocking Nuclear Translocation of ProHB-EGF C-Terminal Fragment in Colon Cancer Cells

BACKGROUND & AIMS: Current treatment target toward advanced colorectal cancers is mainly focused on the epidermal growth factor receptor (EGFR) signaling, but its additive effects with chemotherapy are still limited. A disintegrin and metalloproteinase (ADAM) cleaves the proheparin-binding epide...

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Autori principali: Ozeki, Keiji, Tanida, Satoshi, Morimoto, Chie, Inoue, Yoshimasa, Mizoshita, Tsutomu, Tsukamoto, Hironobu, Shimura, Takaya, Kataoka, Hiromi, Kamiya, Takeshi, Nishiwaki, Eiji, Ishiguro, Hiroshi, Higashiyama, Shigeki, Joh, Takashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579940/
https://ncbi.nlm.nih.gov/pubmed/23451083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056770
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