Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF

Growth factor signaling can affect tissue remodeling through autocrine/paracrine mechanisms. Recent evidence indicates that EGF receptor transactivation by heparin-binding EGF (HB-EGF) contributes to hypertrophic signaling in cardiomyocytes. Here, we show that HB-EGF operates in a spatially restrict...

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Bibliografiske detaljer
Main Authors: Yoshioka, Jun, Prince, Robin N., Huang, Hayden, Perkins, Scott B., Cruz, Francisco U., MacGillivray, Catherine, Lauffenburger, Douglas A., Lee, Richard T.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180761/
https://ncbi.nlm.nih.gov/pubmed/16020536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501198102
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