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Autocrine-Paracrine Prostaglandin E(2) Signaling Restricts TLR4 internalization and TRIF Signaling
The unique cell biology of Toll-like receptor 4 (TLR4) allows it to initiate two signal transduction cascades: a Mal (TIRAP)–MyD88-dependent signal from the cell surface that regulates proinflammatory cytokines and a TRAM–TRIF-dependent signal from endosomes that drives type I interferon production....
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6240378/ https://ncbi.nlm.nih.gov/pubmed/30397349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0243-7 |
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