Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many diseases. ADAM10 and ADAM17 cleave most disease-relevant substrates. Broad-spectrum metalloprotease inhibitors have failed clinically, and t...

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Autori principali: Dang, Michelle, Armbruster, Nicole, Miller, Miles A., Cermeno, Efrain, Hartmann, Monika, Bell, George W., Root, David E., Lauffenburger, Douglas A., Lodish, Harvey F., Herrlich, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683718/
https://ncbi.nlm.nih.gov/pubmed/23720309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307478110
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