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Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways
Ectodomain cleavage of cell-surface proteins by A disintegrin and metalloproteinases (ADAMs) is highly regulated, and its dysregulation has been linked to many diseases. ADAM10 and ADAM17 cleave most disease-relevant substrates. Broad-spectrum metalloprotease inhibitors have failed clinically, and t...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683718/ https://ncbi.nlm.nih.gov/pubmed/23720309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307478110 |
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