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ADAM17 is essential for ectodomain shedding of the EGF‐receptor ligand amphiregulin
The epidermal growth factor (EGF)‐receptor ligand amphiregulin (AREG) is a potent growth factor implicated in proliferative skin diseases and in primary and metastatic epithelial cancers. AREG, synthesized as a propeptide, requires conversion to an active peptide by metalloproteases by a process kno...
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| Publicado no: | FEBS Open Bio |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881543/ https://ncbi.nlm.nih.gov/pubmed/29632822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12407 |
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