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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases. In several instances, ectodomain release is critical for activation of EGFR ligands, highlighting the importance of identifying EGFR ligand s...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172154/ https://ncbi.nlm.nih.gov/pubmed/14993236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307137 |
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