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Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

The cell death receptor Fas plays a role in the establishment of fulminant hepatitis, a major cause of drug-induced liver failure. Fas activation elicits extrinsic apoptotic and hepatoprotective signals; however, the mechanisms by which these signals are integrated during disease are unknown. Tissue...

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Bibliografski detalji
Glavni autori: Murthy, Aditya, Defamie, Virginie, Smookler, David S., Di Grappa, Marco A., Horiuchi, Keisuke, Federici, Massimo, Sibilia, Maria, Blobel, Carl P., Khokha, Rama
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913323/
https://ncbi.nlm.nih.gov/pubmed/20628198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42686
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