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Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding
Proteolytic cleavage of TNF receptor 1 (TNFR1) generates soluble receptors that regulate TNF bioactivity. We hypothesized that the mechanism of TNFR1 shedding might involve interactions with regulatory ectoproteins. Using a yeast two-hybrid approach, we identified ARTS-1 (aminopeptidase regulator of...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150410/ https://ncbi.nlm.nih.gov/pubmed/12189246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13847 |
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