Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding

Proteolytic cleavage of TNF receptor 1 (TNFR1) generates soluble receptors that regulate TNF bioactivity. We hypothesized that the mechanism of TNFR1 shedding might involve interactions with regulatory ectoproteins. Using a yeast two-hybrid approach, we identified ARTS-1 (aminopeptidase regulator of...

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Main Authors: Cui, Xinle, Hawari, Feras, Alsaaty, Sura, Lawrence, Marion, Combs, Christian A., Geng, Weidong, Rouhani, Farshid N., Miskinis, Dianne, Levine, Stewart J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC150410/
https://ncbi.nlm.nih.gov/pubmed/12189246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI13847
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