Activation of TNFR1 ectodomain shedding by mitochondrial Ca(2+) determines the severity of inflammation in mouse lung microvessels

Shedding of the extracellular domain of cytokine receptors allows the diffusion of soluble receptors into the extracellular space; these then bind and neutralize their cytokine ligands, thus dampening inflammatory responses. The molecular mechanisms that control this process, and the extent to which...

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Autori principali: Rowlands, David J., Islam, Mohammad Naimul, Das, Shonit R., Huertas, Alice, Quadri, Sadiqa K., Horiuchi, Keisuke, Inamdar, Nilufar, Emin, Memet T., Lindert, Jens, Ten, Vadim S., Bhattacharya, Sunita, Bhattacharya, Jahar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083796/
https://ncbi.nlm.nih.gov/pubmed/21519143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43839
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