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Activation of TNFR1 ectodomain shedding by mitochondrial Ca(2+) determines the severity of inflammation in mouse lung microvessels
Shedding of the extracellular domain of cytokine receptors allows the diffusion of soluble receptors into the extracellular space; these then bind and neutralize their cytokine ligands, thus dampening inflammatory responses. The molecular mechanisms that control this process, and the extent to which...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083796/ https://ncbi.nlm.nih.gov/pubmed/21519143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43839 |
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