ADAM10-Mediated Ectodomain Shedding Is an Essential Driver of Podocyte Damage

BACKGROUND: Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, which could be mediated by shedding of cell-adhesion...

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Détails bibliographiques
Publié dans:J Am Soc Nephrol
Auteurs principaux: Sachs, Marlies, Wetzel, Sebastian, Reichelt, Julia, Sachs, Wiebke, Schebsdat, Lisa, Zielinski, Stephanie, Seipold, Lisa, Heintz, Lukas, Müller, Stephan A., Kretz, Oliver, Lindenmeyer, Maja, Wiech, Thorsten, Huber, Tobias B., Lüllmann-Rauch, Renate, Lichtenthaler, Stefan F., Saftig, Paul, Meyer-Schwesinger, Catherine
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2021
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259650/
https://ncbi.nlm.nih.gov/pubmed/33785583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020081213
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