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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases. In several instances, ectodomain release is critical for activation of EGFR ligands, highlighting the importance of identifying EGFR ligand s...

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Détails bibliographiques
Auteurs principaux: Sahin, Umut, Weskamp, Gisela, Kelly, Kristine, Zhou, Hong-Ming, Higashiyama, Shigeki, Peschon, Jacques, Hartmann, Dieter, Saftig, Paul, Blobel, Carl P.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172154/
https://ncbi.nlm.nih.gov/pubmed/14993236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307137
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