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Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases. In several instances, ectodomain release is critical for activation of EGFR ligands, highlighting the importance of identifying EGFR ligand s...

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Bibliografski detalji
Glavni autori: Sahin, Umut, Weskamp, Gisela, Kelly, Kristine, Zhou, Hong-Ming, Higashiyama, Shigeki, Peschon, Jacques, Hartmann, Dieter, Saftig, Paul, Blobel, Carl P.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2004
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172154/
https://ncbi.nlm.nih.gov/pubmed/14993236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307137
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