The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release

Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Mol Life Sci
Prif Awduron: Düsterhöft, Stefan, Kahveci-Türköz, Selcan, Wozniak, Justyna, Seifert, Anke, Kasparek, Petr, Ohm, Henrike, Liu, Shixin, Kopkanova, Jana, Lokau, Juliane, Garbers, Christoph, Preisinger, Christian, Sedlacek, Radislav, Freeman, Matthew, Ludwig, Andreas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2021
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233286/
https://ncbi.nlm.nih.gov/pubmed/33950315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-021-03845-3
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