ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1)

The metalloprotease ADAM17 (a disintegrin and metalloprotease 17) is a key regulator of tumor necrosis factor α (TNFα), interleukin 6 receptor (IL-6R), and epidermal growth factor receptor (EGFR) signaling. ADAM17 maturation and function depend on the seven-membrane–spanning inactive rhomboid-like p...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Weskamp, Gisela, Tüshaus, Johanna, Li, Daniel, Feederle, Regina, Maretzky, Thorsten, Swendemann, Steven, Falck-Pedersen, Erik, McIlwain, David R., Mak, Tak W., Salmon, Jane E., Lichtenthaler, Stefan F., Blobel, Carl P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7105298/
https://ncbi.nlm.nih.gov/pubmed/32060096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011136
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