iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding

Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulator of EGF-receptor signaling and TNFα release, is rapidly and posttranslationally activated by a variety of signaling pathways, and yet little is known about the underlying mechanism. Here, we report tha...

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Detalles Bibliográficos
Main Authors: Maretzky, Thorsten, McIlwain, David R., Issuree, Priya Darshinee A., Li, Xue, Malapeira, Jordi, Amin, Sadaf, Lang, Philipp A., Mak, Tak W., Blobel, Carl P.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710827/
https://ncbi.nlm.nih.gov/pubmed/23801765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302553110
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