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iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding
Protein ectodomain shedding by ADAM17 (a disintegrin and metalloprotease 17), a principal regulator of EGF-receptor signaling and TNFα release, is rapidly and posttranslationally activated by a variety of signaling pathways, and yet little is known about the underlying mechanism. Here, we report tha...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3710827/ https://ncbi.nlm.nih.gov/pubmed/23801765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302553110 |
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