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iRHOM2 is a critical pathogenic mediator of inflammatory arthritis
iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase (TACE), which controls shedding of TNF-α and its biological activity in vivo. TACE is a potential target to treat TNF-α–dependent diseases, such as rheumatoid arthritis, but there are concerns about potential side e...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Clinical Investigation
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561822/ https://ncbi.nlm.nih.gov/pubmed/23348744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66168 |
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