iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

iRHOM2, encoded by the gene Rhbdf2, regulates the maturation of the TNF-α convertase (TACE), which controls shedding of TNF-α and its biological activity in vivo. TACE is a potential target to treat TNF-α–dependent diseases, such as rheumatoid arthritis, but there are concerns about potential side e...

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Autors principals: Issuree, Priya Darshinee A., Maretzky, Thorsten, McIlwain, David R., Monette, Sébastien, Qing, Xiaoping, Lang, Philipp A., Swendeman, Steven L., Park-Min, Kyung-Hyun, Binder, Nikolaus, Kalliolias, George D., Yarilina, Anna, Horiuchi, Keisuke, Ivashkiv, Lionel B., Mak, Tak W., Salmon, Jane E., Blobel, Carl P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
Matèries:
Brief Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561822/
https://ncbi.nlm.nih.gov/pubmed/23348744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66168
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