iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam1...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Li, Xue, Maretzky, Thorsten, Weskamp, Gisela, Monette, Sébastien, Qing, Xiaoping, Issuree, Priya Darshinee A., Crawford, Howard C., McIlwain, David R., Mak, Tak W., Salmon, Jane E., Blobel, Carl P.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434755/
https://ncbi.nlm.nih.gov/pubmed/25918388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505649112
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