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iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling
The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam1...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4434755/ https://ncbi.nlm.nih.gov/pubmed/25918388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505649112 |
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