iRhoms 1 and 2 are essential upstream regulators of ADAM17-dependent EGFR signaling

The metalloproteinase ADAM17 (a disintegrin and metalloprotease 17) controls EGF receptor (EGFR) signaling by liberating EGFR ligands from their membrane anchor. Consequently, a patient lacking ADAM17 has skin and intestinal barrier defects that are likely caused by lack of EGFR signaling, and Adam1...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Li, Xue, Maretzky, Thorsten, Weskamp, Gisela, Monette, Sébastien, Qing, Xiaoping, Issuree, Priya Darshinee A., Crawford, Howard C., McIlwain, David R., Mak, Tak W., Salmon, Jane E., Blobel, Carl P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434755/
https://ncbi.nlm.nih.gov/pubmed/25918388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505649112
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