The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release

Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements...

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Bibliographic Details
Published in:Cell Mol Life Sci
Main Authors: Düsterhöft, Stefan, Kahveci-Türköz, Selcan, Wozniak, Justyna, Seifert, Anke, Kasparek, Petr, Ohm, Henrike, Liu, Shixin, Kopkanova, Jana, Lokau, Juliane, Garbers, Christoph, Preisinger, Christian, Sedlacek, Radislav, Freeman, Matthew, Ludwig, Andreas
Format: Artigo
Language:Inglês
Published: Springer International Publishing 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233286/
https://ncbi.nlm.nih.gov/pubmed/33950315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-021-03845-3
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