The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release

Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements...

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Vydáno v:Cell Mol Life Sci
Hlavní autoři: Düsterhöft, Stefan, Kahveci-Türköz, Selcan, Wozniak, Justyna, Seifert, Anke, Kasparek, Petr, Ohm, Henrike, Liu, Shixin, Kopkanova, Jana, Lokau, Juliane, Garbers, Christoph, Preisinger, Christian, Sedlacek, Radislav, Freeman, Matthew, Ludwig, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2021
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233286/
https://ncbi.nlm.nih.gov/pubmed/33950315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-021-03845-3
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