The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release

Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the transport, maturation and activity of ADAM17. Yet, the structural and functional requirements...

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Detaylı Bibliyografya
Yayımlandı:Cell Mol Life Sci
Asıl Yazarlar: Düsterhöft, Stefan, Kahveci-Türköz, Selcan, Wozniak, Justyna, Seifert, Anke, Kasparek, Petr, Ohm, Henrike, Liu, Shixin, Kopkanova, Jana, Lokau, Juliane, Garbers, Christoph, Preisinger, Christian, Sedlacek, Radislav, Freeman, Matthew, Ludwig, Andreas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer International Publishing 2021
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8233286/
https://ncbi.nlm.nih.gov/pubmed/33950315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-021-03845-3
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