Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-β, and TGF-α is specifically triggered by different stimuli and involves different PKC isoenzymes

Metalloproteinase cleavage of transmembrane proteins (ectodomain cleavage), including the epidermal growth factor (EGF) ligands heparin-binding EGF-like growth factor (HB-EGF), neuregulin (NRG), and transforming growth factor-alpha (TGF-α), is important in many cellular signaling pathways and is dis...

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Bibliografiske detaljer
Main Authors: Herrlich, Andreas, Klinman, Eva, Fu, Jonathan, Sadegh, Cameron, Lodish, Harvey
Format: Artigo
Sprog:Inglês
Udgivet: The Federation of American Societies for Experimental Biology 2008
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614613/
https://ncbi.nlm.nih.gov/pubmed/18757500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-113852
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