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Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities
Heparin-binding EGF-like growth factor (HB-EGF) is first synthesized as a membrane-anchored form (proHB-EGF), and its soluble form (sHB-EGF) is released by ectodomain shedding from proHB-EGF. To examine the significance of proHB-EGF processing in vivo, we generated mutant mice by targeted gene repla...
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| Autori principali: | , , , , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173637/ https://ncbi.nlm.nih.gov/pubmed/14597776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307035 |
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