Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities

Heparin-binding EGF-like growth factor (HB-EGF) is first synthesized as a membrane-anchored form (proHB-EGF), and its soluble form (sHB-EGF) is released by ectodomain shedding from proHB-EGF. To examine the significance of proHB-EGF processing in vivo, we generated mutant mice by targeted gene repla...

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Autori principali: Yamazaki, Satoru, Iwamoto, Ryo, Saeki, Kazuko, Asakura, Masanori, Takashima, Seiji, Yamazaki, Ayano, Kimura, Rina, Mizushima, Hiroto, Moribe, Hiroki, Higashiyama, Shigeki, Endoh, Masayuki, Kaneda, Yasufumi, Takagi, Satoshi, Itami, Satoshi, Takeda, Naoki, Yamada, Gen, Mekada, Eisuke
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173637/
https://ncbi.nlm.nih.gov/pubmed/14597776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307035
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