Epidermal Growth Factor (EGF) Ligand Release by Substrate-specific A Disintegrin and Metalloproteases (ADAMs) Involves Different Protein Kinase C (PKC) Isoenzymes Depending on the Stimulus

The dysregulation of EGF family ligand cleavage has severe consequences for the developing as well as the adult organism. Therefore, their production is highly regulated. The limiting step is the ectodomain cleavage of membrane-bound precursors by one of several a disintegrin and metalloprotease (AD...

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Bibliografiske detaljer
Main Authors: Dang, Michelle, Dubbin, Karen, D'Aiello, Antonio, Hartmann, Monika, Lodish, Harvey, Herrlich, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093846/
https://ncbi.nlm.nih.gov/pubmed/21454702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187823
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