Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

The protease a disintegrin and metalloprotease (ADAM) 17 cleaves tumor necrosis factor (TNF), L-selectin, and epidermal growth factor receptor (EGF-R) ligands from the plasma membrane. ADAM17 is expressed in most tissues and is up-regulated during inflammation and cancer. ADAM17-deficient mice are n...

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Detalhes bibliográficos
Main Authors: Chalaris, Athena, Adam, Nina, Sina, Christian, Rosenstiel, Philip, Lehmann-Koch, Judith, Schirmacher, Peter, Hartmann, Dieter, Cichy, Joanna, Gavrilova, Olga, Schreiber, Stefan, Jostock, Thomas, Matthews, Vance, Häsler, Robert, Becker, Christoph, Neurath, Markus F., Reiß, Karina, Saftig, Paul, Scheller, Jürgen, Rose-John, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916135/
https://ncbi.nlm.nih.gov/pubmed/20603312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092366
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