A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)

T cell immunoglobulin and mucin domain 3 (Tim-3) dampens the response of CD4(+) and CD8(+) effector T cells via induction of cell death and/or T cell exhaustion and enhances the ability of macrophages to clear pathogens via binding to galectin 9. Here we provide evidence that human Tim-3 is a target...

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Bibliografiske detaljer
Main Authors: Möller-Hackbarth, Katja, Dewitz, Christin, Schweigert, Olga, Trad, Ahmad, Garbers, Christoph, Rose-John, Stefan, Scheller, Jürgen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843067/
https://ncbi.nlm.nih.gov/pubmed/24121505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.488478
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