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Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization

Ectodomain shedding of transmembrane precursor proteins generates numerous life-essential molecules, such as epidermal growth factor receptor ligands. This cleavage not only releases the regulatory growth factor, but it is also the required first step for the subsequent processing by γ-secretase and...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Hartmann, Monika, Parra, Liseth M., Ruschel, Anne, Lindner, Christina, Morrison, Helen, Herrlich, Andreas, Herrlich, Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498042/
https://ncbi.nlm.nih.gov/pubmed/25925953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610204
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