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Distinct Intracellular Domain Substrate Modifications Selectively Regulate Ectodomain Cleavage of NRG1 or CD44

Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs) releases many important biologically active substrates and is therefore tightly controlled. Part of the regulation occurs on the level of the enzymes and affects their cell surface abundance and catalytic activity. ADAM-dependent pro...

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Bibliografiska uppgifter
I publikationen:Mol Cell Biol
Huvudupphovsmän: Parra, Liseth M., Hartmann, Monika, Schubach, Salome, Li, Yong, Herrlich, Peter, Herrlich, Andreas
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4561721/
https://ncbi.nlm.nih.gov/pubmed/26217011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00500-15
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