ADAM17 substrate release in proximal tubule drives kidney fibrosis

Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. In a study into its molecular mechanism, we identified essential causative features. Acute or chronic kidney injury causes sustained elevation of a disintegrin and metall...

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Vydáno v:JCI Insight
Hlavní autoři: Kefaloyianni, Eirini, Muthu, Muthu Lakshmi, Kaeppler, Jakob, Sun, Xiaoming, Sabbisetti, Venkata, Chalaris, Athena, Rose-John, Stefan, Wong, Eitan, Sagi, Irit, Waikar, Sushrut S., Rennke, Helmut, Humphreys, Benjamin D., Bonventre, Joseph V., Herrlich, Andreas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026414/
https://ncbi.nlm.nih.gov/pubmed/27642633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.87023
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