Application of structural-dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-α converting enzyme (TACE)

Por Sagi, Irit, Milla, Marcos E.
Publicado em 2007

Nucleic acid fragmentation on the millisecond timescale using a conventional X-ray rotating anode source: application to protein–DNA footprinting

Por Henn, Arnon, Halfon, Jacob, Kela, Itai, Orion, Itzhak, Sagi, Irit
Publicado em 2001

The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair

Por Shechter, Ravid, Raposo, Catarina, London, Anat, Sagi, Irit, Schwartz, Michal
Publicado em 2011

ECM remodelling in IBD: innocent bystander or partner in crime? The emerging role of extracellular molecular events in sustaining intestinal inflammation

Por Shimshoni, Elee, Yablecovitch, Doron, Baram, Liran, Dotan, Iris, Sagi, Irit
Publicado no Gut (2015)

Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting

Por Weizman, Tomer, Levin, Itay, Zaretsky, Marianna, Sagi, Irit, Aharoni, Amir
Publicado no Front Mol Biosci (2017)

Key feature of the catalytic cycle of TNF-α converting enzyme involves communication between distal protein sites and the enzyme catalytic core

Por Solomon, Ariel, Akabayov, Barak, Frenkel, Anatoly, Milla, Marcos E., Sagi, Irit
Publicado em 2007

The conserved Glu-60 residue in Thermoanaerobacter brockii alcohol dehydrogenase is not essential for catalysis

Por Kleifeld, Oded, Shi, Shu Ping, Zarivach, Raz, Eisenstein, Miriam, Sagi, Irit
Publicado em 2003

The Functional Maturation of A Disintegrin and Metalloproteinase (ADAM) 9, 10, and 17 Requires Processing at a Newly Identified Proprotein Convertase (PC) Cleavage Site

Por Wong, Eitan, Maretzky, Thorsten, Peleg, Yoav, Blobel, Carl P., Sagi, Irit
Publicado no J Biol Chem (2015)

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

Por Sharabi, Oz, Shirian, Jason, Grossman, Moran, Lebendiker, Mario, Sagi, Irit, Shifman, Julia
Publicado em 2014

Visualization of unwinding activity of duplex RNA by DbpA, a DEAD box helicase, at single-molecule resolution by atomic force microscopy

Por Henn, Arnon, Medalia, Ohad, Shi, Shu-Ping, Steinberg, Michal, Franceschi, Francois, Sagi, Irit
Publicado em 2001

Introduction of correlative light and airSEM(TM) microscopy imaging for tissue research under ambient conditions

Por Solomonov, Inna, Talmi-Frank, Dalit, Milstein, Yonat, Addadi, Sefi, Aloshin, Anna, Sagi, Irit
Publicado no Sci Rep (2014)

Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of membrane type 1 matrix metalloproteinase

Por Ogata, Hideaki, Decaneto, Elena, Grossman, Moran, Havenith, Martina, Sagi, Irit, Lubitz, Wolfgang, Knipp, Markus
Publicado em 2014

Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site

Por Grossman, Moran, Born, Benjamin, Heyden, Matthias, Tworowski, Dmitry, Fields, Gregg B, Sagi, Irit, Havenith, Martina
Publicado em 2011

Zn(2+)-Aβ40 Complexes Form Metastable Quasi-spherical Oligomers That Are Cytotoxic to Cultured Hippocampal Neurons

Por Solomonov, Inna, Korkotian, Eduard, Born, Benjamin, Feldman, Yishay, Bitler, Arkady, Rahimi, Farid, Li, Huiyuan, Bitan, Gal, Sagi, Irit
Publicado em 2012

Direct Visualization of Protease Action on Collagen Triple Helical Structure

Por Rosenblum, Gabriel, Van den Steen, Philippe E., Cohen, Sidney R., Bitler, Arkady, Brand, David D., Opdenakker, Ghislain, Sagi, Irit
Publicado em 2010

Enzymatic turnover of macromolecules generates long-lasting protein–water-coupled motions beyond reaction steady state

Por Dielmann-Gessner, Jessica, Grossman, Moran, Conti Nibali, Valeria, Born, Benjamin, Solomonov, Inna, Fields, Gregg B., Havenith, Martina, Sagi, Irit
Publicado no Proc Natl Acad Sci U S A (2014)

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

Por Wong, Eitan, Cohen, Tal, Romi, Erez, Levin, Maxim, Peleg, Yoav, Arad, Uri, Yaron, Avraham, Milla, Marcos E., Sagi, Irit
Publicado no Sci Rep (2016)

From Sensors to Silencers: Quinoline- and Benzimidazole-Sulfonamides as Inhibitors for Zinc Proteases

Por Rouffet, Matthieu, de Oliveira, César Augusto F., Udi, Yael, Agrawal, Arpita, Sagi, Irit, McCammon, J. Andrew, Cohen, Seth M.
Publicado em 2010

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Por Arkadash, Valeria, Yosef, Gal, Shirian, Jason, Cohen, Itay, Horev, Yuval, Grossman, Moran, Sagi, Irit, Radisky, Evette S., Shifman, Julia M., Papo, Niv
Publicado no J Biol Chem (2017)

Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule

Por Politi, Yael, Metzler, Rebecca A., Abrecht, Mike, Gilbert, Benjamin, Wilt, Fred H., Sagi, Irit, Addadi, Lia, Weiner, Steve, Gilbert, P. U. P. A.
Publicado em 2008