Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Degradation of the extracellular matrices in the human body is controlled by matrix metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in MMP activity can result in many diseases, such as arthritis, cardiovascular diseases, neurological disorders, fibrosis, and cancers...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Arkadash, Valeria, Yosef, Gal, Shirian, Jason, Cohen, Itay, Horev, Yuval, Grossman, Moran, Sagi, Irit, Radisky, Evette S., Shifman, Julia M., Papo, Niv
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336179/
https://ncbi.nlm.nih.gov/pubmed/28087697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756718
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