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Targeting the MMP-14/MMP-2/integrin α(v)β(3) axis with multispecific N-TIMP2–based antagonists for cancer therapy
The pathophysiological functions of the signaling molecules matrix metalloproteinase-14 (MMP-14) and integrin α(v)β(3) in various types of cancer are believed to derive from their collaborative activity in promoting invasion, metastasis, and angiogenesis, as shown in vitro and in vivo. The two effec...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6109916/ https://ncbi.nlm.nih.gov/pubmed/29986882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004406 |
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