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Targeting the MMP-14/MMP-2/integrin α(v)β(3) axis with multispecific N-TIMP2–based antagonists for cancer therapy

The pathophysiological functions of the signaling molecules matrix metalloproteinase-14 (MMP-14) and integrin α(v)β(3) in various types of cancer are believed to derive from their collaborative activity in promoting invasion, metastasis, and angiogenesis, as shown in vitro and in vivo. The two effec...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Yosef, Gal, Arkadash, Valeria, Papo, Niv
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109916/
https://ncbi.nlm.nih.gov/pubmed/29986882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004406
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