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Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell
Developing selective inhibitors for proteolytic enzymes that share high sequence homology and structural similarity is important for achieving high target affinity and functional specificity. Here, we used a combination of yeast surface display and dual-color selective library screening to obtain se...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6112833/ https://ncbi.nlm.nih.gov/pubmed/30174795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25885 |
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