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Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell

Developing selective inhibitors for proteolytic enzymes that share high sequence homology and structural similarity is important for achieving high target affinity and functional specificity. Here, we used a combination of yeast surface display and dual-color selective library screening to obtain se...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Arkadash, Valeria, Radisky, Evette S., Papo, Niv
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6112833/
https://ncbi.nlm.nih.gov/pubmed/30174795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25885
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